Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy

Abstract Background Patient-specific active fluid–structure interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in heart. However, it takes lot of effort obtain proper external force boundary conditions for models, which heavily restrained time-sensitive clinical applications computational models. Methods The simulation results 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding differences cardiac mechanics between these Results In comparing was found that there no significant difference pressure shear stress mitral valve leaflet (MVL) at pre-SAM time point, but wall inner left ventricle (endocardium). It also coapted MVL significantly decreased after successful surgery both Conclusion Our suggested may provide good approximated hemodynamic 5% RR interval, crucial analyzing initiation systolic anterior motion (SAM). Comparing decrease complexity modeling construction difficulty convergence significantly. These findings suggest that, sufficient data, be substitution perform analysis SAM.